Anti-CNOT7 (N19) Antibody

• Description:

  Boster Bio Anti-CNOT7 (N19) Antibody catalog # A04884. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  CCR4-NOT transcription complex subunit 7;3.1.13.4; BTG1-binding factor 1; CCR4-associated factor 1; CAF-1; Caf1a; CNOT7; CAF1;

• Gene Name:

  CNOT7

• UniProt:

  Q9UIV1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide, corresponding to amino acids 10-54 of Human CNOT7

• Clonality:

  Polyclonal

• Applications:

  WB

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)

• Dilution:

  WB: 1:500-1:1000

• Form:

  Liquid

• Function:

  Has 3'-5' poly (A) exoribonuclease activity for synthetic poly (A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti- proliferative activity.

• Molecular Weight:

  32745 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  CCR4-NOT transcription complex subunit 7

• Subcellular Location:

  Nucleus. Cytoplasm, P-body . NANOS2 promotes its localization to P-body. .

• Protein Name:

  CCR4-NOT transcription complex subunit 7