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Anti-CNOT7 Antibody

CAT: 0519-A04884-1Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A04884-1Size:100 µL
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Description
Boster Bio Anti-CNOT7 Antibody catalog # A04884-1. Tested in WB applications. This antibody reacts with Human, Mouse.
Synonyms
CCR4-NOT transcription complex subunit 7;3.1.13.4; BTG1-binding factor 1; CCR4-associated factor 1; CAF-1; Caf1a; CNOT7; CAF1
Gene Name
CNOT7
UniProt
Q9UIV1
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human CNOT7. AA range:10-59
Applications
WB
Purification
Immunogen affinity purified
Dilution
WB, 1:500-1:2000
Form
Liquid
Function
Has 3'-5' poly (A) exoribonuclease activity for synthetic poly (A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti- proliferative activity. .
Molecular Weight
32745 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
CCR4-NOT transcription complex subunit 7
Subcellular Location
Nucleus. Cytoplasm, P-body . NANOS2 promotes its localization to P-body. .

UniProtKB · Q9UIV1

CCR4-NOT transcription complex subunit 7

CNOT7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9UIV1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CNOT7
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.13.4
Processing
—
Secondary accessions
A8MZM5, B3KMP1, B3KN35, D3DSP6, G3V108, Q7Z530
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Molecular function

ExonucleaseHydrolaseNucleaseRepressorRNA-binding

Ligand

MagnesiumMetal-binding

Biological process

RNA-mediated gene silencingTranscriptionTranscription regulationTranslation regulation