Anti-HSP60 (T547) HSPD1 Antibody

• Description:

  Boster Bio Anti-HSP60 (T547) HSPD1 Antibody catalog # A01280T547. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  60 kDa heat shock protein, mitochondrial;3.6.4.9;60 kDa chaperonin; Chaperonin 60; CPN60; Heat shock protein 60; HSP-60; Hsp60; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein; HSPD1; HSP60;

• Gene Name:

  HSPD1

• UniProt:

  P10809

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide, corresponding to amino acids 511-560 of Human HSP60.

• Clonality:

  Polyclonal

• Applications:

  WB, IHC, IF

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Form:

  Liquid

• Function:

  Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:1346131, PubMed:11422376) . The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable) .

• Molecular Weight:

  61055 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  60 kDa heat shock protein, mitochondrial

• Subcellular Location:

  Mitochondrion matrix.

• Protein Name:

  60 kDa heat shock protein, mitochondrial