Human Complement Component C1Q Receptor, CD93 Primacu™ ELISA Kit

Human Complement Component C1Q Receptor, CD93 Primacu™ ELISA Kit

• Background: CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protein expressed on monocytes, neutrophils, endothelial cells, and stem cells. CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. CD93/C1qR, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. CD93 is important for the maintenance of plasma cells in bone marrow niches.
• Description: Complement component C1q receptor
• Synonyms: C1QR1;MXRA4
• Gene Name: CD93
• Gene ID: 22918
• UniProt: Q9NPY3
• Origin Species: Human
• Reactivity: Human
• Target: CD93
• Field of Research: Cardiovascular,Immunology,Stem cells
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 20 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 31.25-2000 pg/mL
• Sensitivity: 10.56 pg/mL
• Weight: 68560
• Storage Temperature: 2-8°C