Azido-PEG6-alcohol

CAT:

804-HY-130537-03

Size:

500 mg

Price:

Ask

For price, please contact [email protected]

CAS Number: 86770-69-6
UNSPSC Description: Azido-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-alcohol is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Azido-PEG6-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Target Antigen: ADC Linker; PROTAC Linkers
Type: ADC Related
Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC
Field of Research: Cancer
Assay Protocol: https://www.medchemexpress.com/azido-peg6-alcohol.html
Purity: 98.0
Solubility: 10 mM in DMSO
Smiles: OCCOCCOCCOCCOCCOCCN=[N+]=[N-]
Molecular Weight: 307.34
References & Citations: [1]Zorba A, et al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292.|[2]Loredana Vesci, et al. HDAC INHIBITORS-BASED ANTIBODY DRUG CONJUGATES (ADCs) AND USE IN THERAPY. WO2018178060A1.
Shipping Conditions: Room Temperature
Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
Clinical Information: No Development Reported