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Azido-PEG6-azide

CAT: 0804-HY-133393-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-133393-01Size:5 mg
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Description
Azido-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
1243536-56-2
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg6-azide.html
Purity
96.16
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
Molecular Formula
C14H28N6O6
Molecular Weight
376.41
Precautions
H302, H315, H319, H335
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers

Chemical Information

Azido-PEG6-azide
CAS Number1243536-56-2
PubChem CID118796295
IUPAC Name1-azido-2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethane
Molecular FormulaC14H28N6O6
Molecular Weight376.41
XLogP1.2
Topological Polar Surface Area84.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count21
Heavy Atom Count26
Formal Charge0
Complexity354
SMILES
C(COCCOCCOCCOCCOCCOCCN=[N+]=[N-])N=[N+]=[N-]
InChI
InChI=1S/C14H28N6O6/c15-19-17-1-3-21-5-7-23-9-11-25-13-14-26-12-10-24-8-6-22-4-2-18-20-16/h1-14H2
InChIKey
AHAONOKFDHURRK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Azido-PEG6-azide
CAS: 1243536-56-2
CID: 118796295
Formula: C14H28N6O6
MW: 376.41
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight376.41
XLogP31.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count21
Exact Mass376.20703263
Monoisotopic Mass376.20703263
Topological Polar Surface Area84.1 Ų
Heavy Atom Count26
Formal Charge0
Complexity354
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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