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Lubiprostone-d7

CAT: 0804-HY-B0679S-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0679S-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lubiprostone-d7 (RU-0211-d7) is the deuterium labeled Lubiprostone. Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin -induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research[1][2][3].
CAS Number
1217675-13-2
Product Name Alternative
RU-0211-d7; SPI-0211-d7
UNSPSC
12352211
Target
CFTR; Chloride Channel; Glutathione Peroxidase; Isotope-Labeled Compounds; NO Synthase; TNF Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Solubility
10 mM in DMSO
Smiles
C(CC(C(CC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])(F)F)=O)[C@@H]1[C@@H](CCCCCCC(O)=O)C(=O)C[C@H]1O
Molecular Formula
C20H25D7F2O5
Molecular Weight
397.51
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]http://en.wikipedia.org/wiki/Lubiprostone
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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Alternative Products

CatalogName
TRC-L473503-5MGLubiprostone-d7
021587O-Tetrahydropyranyl Lubiprostone-d7
CS-O-1116715-Hydroxy Lubiprostone-d7
CS-T-9363115-Hydroxy Lubiprostone Dicyclohexylammonium-d7
AR-L07903-01Lubiprostone-d7 (Mixture of Tautomeric Isomers)
TRC-H943892-0.25MG15-Hydroxy Lubiprostone Dicyclohexylammonium Salt-d7
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