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Lubiprostone

CAT: 0804-HY-B0679-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0679-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin -induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research[1][2][3].
CAS Number
136790-76-6
Product Name Alternative
RU-0211; SPI-0211
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
CFTR; Chloride Channel; Glutathione Peroxidase; NO Synthase; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lubiprostone.html
Purity
99.09
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(F)(F)CCCC)CC[C@@H]([C@@H](C1)O)[C@H](C1=O)CCCCCCC(O)=O
Molecular Formula
C20H32F2O5
Molecular Weight
390.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Ao M, et al., Lubiprostone activates Cl- secretion via cAMP signaling and increases membrane CFTR in the human colon carcinoma cell line, T84. Dig Dis Sci. 2011 Feb;56 (2) :339-51.|[2]Kim MY, et al., Lubiprostone significantly represses fatty liver diseases via induction of mucin and HDL release in mice. Life Sci. 2022 Dec 15;311 (Pt A) :121176.|[3]Hayashi S, et al., Lubiprostone prevents nonsteroidal anti-inflammatory drug-induced small intestinal damage by suppressing the expression of inflammatory mediators via EP4 receptors. J Pharmacol Exp Ther. 2014 Jun;349 (3) :470-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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