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LAT rabbit pAb

CAT: 0855-ES8350-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8350-01Size:50 µL
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Background
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Product Name Alternative
LAT; Linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; pp36; p36-38
UniProt
O43561
Swiss Prot
O43561
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from LAT . at AA range: 190-270
Target
LAT
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Buffer
-20°C/1 year
Molecular Weight
27kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
27kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type III membrane protein . Present in lipid rafts.
Other Product Names
LAT; Linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; pp36; p36-38
Gene ID (Human)
27040

UniProtKB · O43561

Linker for activation of T-cells family member 1

LAT_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43561
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LAT
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B7WPI0, C7C5T6, G5E9K3, O43919
Protein keywords

Biological process

Adaptive immunityImmunityMast cell degranulation

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembrane

Technical term

Direct protein sequencingProteomics identificationReference proteome

PTM

LipoproteinPalmitatePhosphoproteinUbl conjugation

Domain

Signal-anchorTransmembraneTransmembrane helix

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