Guanidine-13C,15N3 (hydrochloride)

Guanidine-13C,15N3 (hydrochloride)

• CAS Number: 285977-73-3
• UNSPSC Description: Guanidine-13C,15N3 (hydrochloride)is the 13C-labeled and 15N-labeled Guanidine hydrochloride. Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins[1][2].
• Target Antigen: Endogenous Metabolite; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Metabolic Enzyme/Protease;Others
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/guanidine-13c-15n3-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: [H]Cl.[15NH]=[13C]([15NH2])[15NH2]
• Molecular Weight: 99.50
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Y Hagihara, et al. Guanidine hydrochloride-induced folding of proteins. J Mol Biol. 1993 May 20;231(2):180-4.|[3]G Jung, et al. Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions. Curr Microbiol. 2001 Jul;43(1):7-10.|[4]Saeed Emadi, et al. A comparative study on the aggregating effects of guanidine thiocyanate, guanidine hydrochloride and urea on lysozyme aggregation. Biochem Biophys Res Commun. 2014 Aug 8;450(4):1339-44.|[5]E C Herrmann Jr, et al. Prevention of death in mice infected with coxsackievirus A16 using guanidine HCl mixed with substituted benzimidazoles. Antiviral Res. 1982 Dec;2(6):339-46.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported