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Guanidine (hydrochloride)

CAT: 0804-HY-B0178A-01Size: 25 gDry Ice: NoHazardous: No
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CAT#:0804-HY-B0178A-01Size:25 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins[1][2].
CAS Number
50-01-1
Product Name Alternative
Guanidinium (chloride) ; Aminoformamidine (hydrochloride)
UNSPSC
12352211
Hazard Statement
H302+H332, H315, H319, H402
Target
Autophagy; Endogenous Metabolite
Type
Natural Products
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/guanidine-hydrochloride.html
Purity
99.9
Solubility
DMSO : ≥ 100 mg/mL|H2O : 100 mg/mL (ultrasonic)
Smiles
NC(N)=N.Cl
Molecular Formula
CH6ClN3
Molecular Weight
95.53
Precautions
H302+H332, H315, H319, H402
References & Citations
[1]Y Hagihara, et al. Guanidine hydrochloride-induced folding of proteins. J Mol Biol. 1993 May 20;231 (2) :180-4.|[2]G Jung, et al. Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions. Curr Microbiol. 2001 Jul;43 (1) :7-10.|[3]Saeed Emadi, et al. A comparative study on the aggregating effects of guanidine thiocyanate, guanidine hydrochloride and urea on lysozyme aggregation. Biochem Biophys Res Commun. 2014 Aug 8;450 (4) :1339-44.|[4]E C Herrmann Jr, et al. Prevention of death in mice infected with coxsackievirus A16 using guanidine HCl mixed with substituted benzimidazoles. Antiviral Res. 1982 Dec;2 (6) :339-46.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature, keep dry and cool
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite

Chemical Information

Guanidine Hydrochloride

Guanidine Hydrochloride is the hydrochloride salt form of guanidine, a strong basic compound with parasympathomimetic activity. Guanidine hydrochloride enhances the release of acetylcholine following a nerve impulse and potentiates acetylcholine actions on muscarinic and nicotinic receptors. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes. (NCI05)

CAS Number50-01-1
PubChem CID5742
IUPAC Nameguanidine;hydrochloride
Molecular FormulaCH6ClN3
Molecular Weight95.53
Topological Polar Surface Area75.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Heavy Atom Count5
Formal Charge0
Complexity26
SMILES
C(=N)(N)N.Cl
InChI
InChI=1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H
InChIKey
PJJJBBJSCAKJQF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Guanidine Hydrochloride
CAS: 50-01-1
CID: 5742
Formula: CH6ClN3
MW: 95.53
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight95.53
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass95.0250249
Monoisotopic Mass95.0250249
Topological Polar Surface Area75.9 Ų
Heavy Atom Count5
Formal Charge0
Complexity26.3
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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