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TLR-3 Recombinant Protein

CAT: 0013-GTR18911699-01Size: 0.005 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18911699-01Size:0.005 mg
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Description
TLR-3 Recombinant Protein
Product Name Alternative
CD283, IIAE2, Toll-like receptor 3
UniProt
O15455
Source
HEK293 cells
Field of Research
Immunology & Inflammation, Signal Transduction
Purity
Greater than 95% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg) .
Bioactivity
Biological activity was determined by its ability to neutralize Poly I:C induced NF-kappa beta signaling in HT-29 cells stably transfected with NF-kappa beta-luc. The ED50 for this effect is 5-10 ug/ml.”
Form
Lyophilized
Storage Conditions
The lyophilized TLR-3 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TLR-3 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing TLR-3 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Notes
For research use only.
NCBI Accession Number
NP_003256.1
AA Sequence
STTKCTVSHE VADCSHLKLT QVPDDLPTNI TVLNLTHNQL RRLPAANFTR YSQLTSLDVG FNTISKLEPE LCQKLPMLKV LNLQHNELSQ LSDKTFAFCT NLTELHLMSN SIQKIKNNPF VKQKNLITLD LSHNGLSSTK LGTQVQLENL QELLLSNNKI QALKSEELDI FANSSLKKLE LSSNQIKEFS PGCFHAIGRL FGLFLNNVQL GPSLTEKLCL ELANTSIRNL SLSNSQLSTT SNTTFLGLKW TNLTMLDLSY NNLNVVGNDS FAWLPQLEYF FLEYNNIQHL FSHSLHGLFN VRYLNLKRSF TKQSISLASL PKIDDFSFQW LKCLEHLNME DNDIPGIKSN MFTGLINLKY LSLSNSFTSL RTLTNETFVS LAHSPLHILN LTKNKISKIE SDAFSWLGHL EVLDLGLNEI GQELTGQEWR GLENIFEIYL SYNKYLQLTR NSFALVPSLQ RLMLRRVALK NVDSSPSPFQ PLRNLTILDL SNNNIANIND DMLEGLEKLE ILDLQHNNLA RLWKHANPGG PIYFLKGLSH LHILNLESNG FDEIPVEVFK DLFELKIIDL GLNNLNTLPA SVFNNQVSLK SLNLQKNLIT SVEKKVFGPA FRNLTELDMR FNPFDCTCES IAWFVNWINE THTNIPELSS HYLCNTPPHY HGFPVRLFDT SSCKDSAPFE L

UniProtKB · O15455

Toll-like receptor 3

TLR3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15455
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TLR3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B2RAI7, B7Z7K0, E6Y0F0, E6Y0F1, E9PGH4, Q4VAL2, Q504W0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Disease variant

PTM

Disulfide bondGlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Cellular component

Endoplasmic reticulumEndosomeMembrane

Biological process

ImmunityInflammatory responseInnate immunity

Domain

Leucine-rich repeatRepeatSignalTransmembraneTransmembrane helix

Molecular function

ReceptorRNA-binding