TRPC4/5-IN-2

• UNSPSC Description:

  TRPC4/5-IN-2 (Compound 12) is an orally effective transient receptor potential (TRPC5) inhibitor with a IC50 value of 81 nM. TRPC4/5-IN-2 has good biosafety and low liver and kidney toxicity, and is expected to play an important role in the treatment of chronic kidney disease (CKD)[1].

• Target Antigen:

  TRP Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/trpc4-5-in-2.html

• Smiles:

  O=C1C(Cl)=C(N2CCN3C(C2)=NC=C3C(C4=C(Cl)C=C(F)C=C4)OC)C=NN1

• Molecular Weight:

  424.26

• References & Citations:

  [1]Xu Yuanyuan, et al. Discovery of pyridazinone derivatives bearing tetrahydroimidazo[1,2-a] pyrazine scaffold as potent inhibitors of transient receptor potential canonical 5 to ameliorate hypertension-induced renal injury in rats. Eur.J.Med.Chem. 2024, 275:116565.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 2