TRPC4/5-IN-2

TRPC4/5-IN-2

• UNSPSC Description: TRPC4/5-IN-2 (Compound 12) is an orally effective transient receptor potential (TRPC5) inhibitor with a IC50 value of 81 nM. TRPC4/5-IN-2 has good biosafety and low liver and kidney toxicity, and is expected to play an important role in the treatment of chronic kidney disease (CKD)[1].
• Target Antigen: TRP Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/trpc4-5-in-2.html
• Smiles: O=C1C(Cl)=C(N2CCN3C(C2)=NC=C3C(C4=C(Cl)C=C(F)C=C4)OC)C=NN1
• Molecular Weight: 424.26
• References & Citations: [1]Xu Yuanyuan, et al. Discovery of pyridazinone derivatives bearing tetrahydroimidazo[1,2-a] pyrazine scaffold as potent inhibitors of transient receptor potential canonical 5 to ameliorate hypertension-induced renal injury in rats. Eur.J.Med.Chem. 2024, 275:116565.
• Shipping Conditions: Room temperature
• Clinical Information: Phase 2