TRPC4/5-IN-1

TRPC4/5-IN-1

• CAS Number: 3032263-08-1
• UNSPSC Description: TRPC4/5-IN-1 is a potent TRP channel 4/5 (TRPC4/5) inhibitor with IC50s of 2.06 μM and 0.54 μM, respectively. TRPC4/5-IN-1 can be used for proteinuric kidney diseases and skin inflammatory diseases research[1].
• Target Antigen: TRP Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/trpc4-5-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: CCC1=CC=C(N(CC2=CC=CC=C2)C(NCC3=CC=CO3)=N4)C4=C1
• Molecular Weight: 331.41
• References & Citations: [1]Lili Chen, et al. Synthesis of AC1903 analogs as potent transient receptor potential canonical channel 4/5 inhibitors and biological evaluation. Bioorg Med Chem. 2022 May 27;68:116853.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported