TRPC4/5-IN-1

• UNSPSC Description:

  TRPC4/5-IN-1 is a potent TRP channel 4/5 (TRPC4/5) inhibitor with IC50s of 2.06 μM and 0.54 μM, respectively. TRPC4/5-IN-1 can be used for proteinuric kidney diseases and skin inflammatory diseases research[1].

• Target Antigen:

  TRP Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/trpc4-5-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCC1=CC=C(N(CC2=CC=CC=C2)C(NCC3=CC=CO3)=N4)C4=C1

• Molecular Weight:

  331.41

• References & Citations:

  [1]Lili Chen, et al. Synthesis of AC1903 analogs as potent transient receptor potential canonical channel 4/5 inhibitors and biological evaluation. Bioorg Med Chem. 2022 May 27;68:116853.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3032263-08-1