TP-004

TP-004

• CAS Number: 1454299-21-8
• UNSPSC Description: TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM[1].
• Target Antigen: MetAP
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/tp-004.html
• Purity: 98.89
• Solubility: DMSO : 250 mg/mL (ultrasonic)
• Smiles: O[C@H]1CN(C2=NC=C(C3=CC(C(F)(F)F)=CC4=C3C=NN4)C(C)=N2)CC1
• Molecular Weight: 363.34
• References & Citations: [1]Cheruvallath, Z., et al. Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design—Part 1. Bioorganic & Medicinal Chemistry Letters, 26(12), 2774–2778.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported