Phospho-IRF3 (S396) Recombinant Rabbit Monoclonal Antibody [PSH06-75]

Phospho-IRF3 (S396) Recombinant Rabbit Monoclonal Antibody [PSH06-75]

• Description: Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor. IRF3 is a member of the interferon regulatory transcription factor (IRF) family. IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association domain and several regulatory phosphorylation sites. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. The complex translocates into the nucleus for the transcriptional activation of interferons alpha and beta, and further interferon-induced genes.
• Product Name Alternative: IIAE7 antibody Interferon regulatory factor 3 antibody IRF 3 antibody IRF-3 antibody IRF3 antibody IRF3_HUMAN antibody MGC94729 antibody
• Abbreviation: IRF-3, IRF3
• CAS Number: 9000-83-3
• Swiss Prot: Q14653 Human, P70671 Mouse,
• Cellular Locus: Cytoplasm, Nucleus, Mitochondrion.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser396 of human IRF3.
• Isotype: IgG
• Clone: PSH06-75
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, IF-Cell, FC
• Positive Control: HT-29 transfected with 2.5μg/mL Poly (I:C) for 6 hours cell lysate, J774A.1 transfected with 2.5μg/mL Poly (I:C) for 6 hours cell lysate, human testis tissue, HT-29 cells transfected withPoly (I:C).
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:200 ;IF-Cell: 1:100 ;FC: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 47 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes