Human LOXL2 Protein

Lysyl oxidase homolog 2 is also known as LOXL2, Lysyl oxidase-like protein 2, which is expressed in many tissues, highest expression in reproductive tissues, placenta, uterus and prostate, Up-regulated in a number of cancers cells and tissues. LOXL2 mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) . When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. LOXL2 acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. LOXL2 acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.

Lysyl oxidase homolog 2, LOXL2

Q9Y4K0

Gln 26 - Gln 774

Human

Unconjugated

C-10xHis

Human LOXL2, His Tag (orb864205) is expressed from human 293 cells (HEK293) . It contains AA Gln 26 - Gln 774 (Accession # Q9Y4K0-1) .

Metabolism Research

1.0 EU per μg

95%

Liquid

86.0 kDa

-70°C

For research use only.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 86.0 kDa. The protein migrates as 100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Q9Y4K0