SHMT-IN-2

• Description :

  SHMT-IN-2 is a stereo specific inhibitor of human SHMT1/2 with IC50 values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 can block the growth of many human cancer cells, and has sensitivity for B-cell lymphomas[1].

• CAS Number :

  [2102681-49-0]

• UNSPSC :

  12352005

• Target :

  SHMT

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cancer; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/shmt-in-2.html

• Purity :

  99.60

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  NC1=C(C#N)C(C2=CC(N3CCCC3)=CC(C(F)(F)F)=C2)(C(C)C)C(C(C)=NN4)=C4O1

• Molecular Formula :

  C22H24F3N5O

• Molecular Weight :

  431.45

• References & Citations :

  [1]regory S Ducker, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114 (43) :11404-11409.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported