1-Naphthyl 3,5-dinitrobenzoate

1-Naphthyl 3,5-dinitrobenzoate

• CAS Number: 93261-39-3
• UNSPSC Description: 1-Naphthyl 3,5-dinitrobenzoate is a potent 5-lipoxygenase inhibitor with IC50 values of 1.04 µM and 3.6 µM for 5-LOX and mPGES-1, respectively. 1-Naphthyl 3,5-dinitrobenzoate has strong inhibition activity in the human whole blood (HWB) assay with an IC50 value of 8.6 μM. 1-Naphthyl 3,5-dinitrobenzoate can be used in research of inflammation[1].
• Target Antigen: Lipoxygenase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/1-naphthyl-3-5-dinitrobenzoate.html
• Purity: 99.49
• Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(OC1=C2C=CC=CC2=CC=C1)C3=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C3
• Molecular Weight: 338.27
• References & Citations: [1]Wu Y, et, al. Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors. J Med Chem. 2012 Mar 22;55(6):2597-605.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported