1-(1-Naphthyl)piperazine (hydrochloride)

• UNSPSC Description:

  1-1-Naphthylpiperazine hydrochloride (1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride) is a serotonergic derivative of quipazine, which is both an agonist for 5-HT1A receptor and an antagonist for 5-HT2A receptor. 1-1-Naphthylpiperazine hydrochloride induces cell apoptosis. 1-1-Naphthylpiperazine hydrochloride prevents the immunosuppression and photocarcinogenesis[1].

• Target Antigen:

  5-HT Receptor; Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;GPCR/G Protein;Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/1-1-naphthyl-piperazine-hydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C12=C(C=CC=C2N3CCNCC3)C=CC=C1.Cl

• Molecular Weight:

  248.75

• References & Citations:

  [1]Menezes AC, et al., Cytotoxic effect of the serotonergic drug 1-(1-Naphthyl)piperazine against melanoma cells. Toxicol In Vitro. 2018 Mar;47:72-78.|[2]Sreevidya CS, et al., Agents that reverse UV-Induced immune suppression and photocarcinogenesis affect DNA repair. J Invest Dermatol. 2010 May;130(5):1428-37.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  104113-71-5