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HPG1860

CAT: 0804-HY-169792-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-169792-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HPG1860 is an orally active, highly selective and potent FXR agonist, with an EC50 of 18 nM (FXR-luciferase reporter assay) . HPG1860 has EC50 values >30.0 μM for TGR5 and 13 other related nuclear receptors (cAMP biological assay) . HPG1860 can be used for the research of non-alcoholic steatohepatitis (NASH) [1].
CAS Number
2226133-29-3
UNSPSC
12352100
Target
Aminotransferases (Transaminases) ; FXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hpg1860.html
Smiles
ClC(C=CC=C1Cl)=C1C2=NOC(C3CC3)=C2CN4C[C@H](N(C5=NC6=C(OC)C=C(C(O)=O)C=C6S5)CC4)C
Molecular Formula
C27H26Cl2N4O4S
Molecular Weight
573.49
References & Citations
[1]Mo C, et al. Discovery of HPG1860, a Structurally Novel Nonbile Acid FXR Agonist Currently in Clinical Development for the Treatment of Nonalcoholic Steatohepatitis. Journal of medicinal chemistry. 2023, 66 (14), 9363–9375.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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CatalogName
GTR19239541-01HPG1860

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