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CLCN3 rabbit pAb

CAT: 0855-ES17381-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES17381-01Size:50 µL
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Background
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA) -activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca (2+) /calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Description
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca (2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],
UniProt
P51790
Swiss Prot
P51790
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human CLCN3 AA range: 597-647
Target
CLCN3
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
[Isoform 1]: Early endosome membrane ; Multi-pass membrane protein . Late endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Isoform 1 is localized mainly in late endosomes. .; [Isoform 2]: Golgi apparatus membrane ; Multi-pass membrane protein . Cell projection, ruffle membrane ; Multi-pass membrane protein . Isoform 2 is mainly enriched in the Golgi (PubMed:12471024) . Colocalizes with SLC9A3R1/EBP50 in membrane ruffles (PubMed:11967229) . .
Gene ID (Human)
1182

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