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NSD-IN-3

CAT: 0804-HY-162308-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-162308-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSD-IN-3 (compound 3) is a potent nuclear receptor binding SET domain (NSD) inhibitor. NSD-IN-3 inhibits NSD2-SET and NSD3-SET with IC50 values of 0.81 μM and 0.84 μM, respectively. NSD-IN-3 inhibits histone H3K36 dimethylation and decreases the expression of NSDs-targeted genes in non-small cell lung cancer cells. NSD-IN-3 induces s-phase cell cycle arrest and apoptosis[1].
CAS Number
744260-15-9
UNSPSC
12352005
Target
Apoptosis; Histone Methyltransferase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsd-in-3.html
Purity
98.0
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
NC1=C2C(N(CCOC3=CC=C(Br)C=C3)C=N2)=NC=N1
Molecular Formula
C13H12BrN5O
Molecular Weight
334.17
References & Citations
[1]Lianhua Piao, et al. Discovery of potent small molecule inhibitors of histone lysine methyltransferase NSDs. Eur J Med Chem. 2024 Feb 20:268:116264.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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