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BODIPY-Cyclopamine

CAT: 0804-HY-137115-01Size: 250 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-137115-01Size:250 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BODIPY-Cyclopamine is a fluorescently labeled ligand for the Smoothened (SMO) receptor. The activation of SMO is regulated by Patch protein, and over-activated SMO signaling pathways are associated with tumorigenesis. The NanoBRET (Nanofluorescein bioluminescence resonance energy transfer) technique used in the study can sensitively detect the resonance energy transfer between SMO and BODIPY-Cyclopamine, which can be used for high-throughput screening and kinetic analysis. Studying the binding site of BODIPY-Cyclopamine on SMO can also further explore SMO-targeted drugs[1].
CAS Number
334658-24-1
UNSPSC
12171500
Target
Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bodipy-cyclopamine.html
Smiles
C[C@H]1[C@@]2(O[C@@](C[C@@H]3C)([H])[C@@]1([H])N(C3)CCNC(CCCCCNC(CCC4=CC=C(C=C(C(C)=C5)[N]6=C5C)[N-]4[B+3]6([F-])[F-])=O)=O)C(C)=C(C[C@@]7([H])[C@@]8([H])CC=C(C9)[C@@]7(CC[C@@H]9O)C)[C@@]8([H])CC2
Molecular Formula
C49H70BF2N5O4
Molecular Weight
841.92
References & Citations
[1]A NanoBRET-Based Binding Assay for Smoothened Allows Real-time Analysis of Ligand Binding and Distinction of Two Binding Sites for BODIPY-cyclopamine
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

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