R-10015

• UNSPSC Description:

  R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1[1].

• Target Antigen:

  LIM Kinase (LIMK); Reverse Transcriptase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Cell Cycle/DNA Damage

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/r-10015.html

• Purity:

  99.72

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC=C2NC(C3CCN(C4=C5C(NC=C5Cl)=NC=N4)CC3)=NC2=C1)OC

• Molecular Weight:

  410.86

• References & Citations:

  [1]Yi F, et al. Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1. J Virol. 2017 Jun 9;91(13). pii: e02418-16.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  2097938-51-5