LIGHT/TNFSF14, Human (HEK293, Fc)

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

Alternative Products

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UA040352-P-05	LIGHT/TNFSF14 Protein, Human
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UA040352-P-02	LIGHT/TNFSF14 Protein, Human
UA040352-P-03	LIGHT/TNFSF14 Protein, Human
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RQ7564	Light Antibody / Tnfsf14
E42EH-235	Human LIGHT / TNFSF14 ELISA KIT
EF000247	Human TNFSF14/LIGHT ELISA KIT
EK5462	Human TNFSF14/LIGHT ELISA Kit

CAT:

804-HY-P73281-02

Size:

50 µg

Price:

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For price, please contact [email protected].

LIGHT/TNFSF14, Human (HEK293, Fc)

UNSPSC Description: LIGHT/TNFSF14 protein (CD258; TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type [1]. LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNγ, triggering tumor apoptosis signal [2]. LIGHT/TNFSF14 is also involved in the dominant LTβR-NIK-p52 NF-κB pathway promoting the expression of inflammatory gene[3]. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection[4]. Human LIGHT/TNFSF14 Protein has 240 amino acids and a transmembrane domain (38-58 a.a.). LIGHT/TNFSF14 Protein, Human (HEK293, Fc) is the extracellular part (D74-V240) of human LIGHT/TNFSF14 Protein, produced by HEK293 cells, with a N-terminal hFc-tag.
Type: Recombinant Proteins
Assay Protocol: https://www.medchemexpress.com/cytokines/light-tnfsf14-protein-human-hek293-fc.html
Purity: 91.00
Smiles: DGPAGSWEQL IQERRSHEVN PAAHLTGANS SLTGSGGPLL WETQLGLAFL RGLSYHDGAL VVTKAGYYYI YSKVQLGGVG CPLGLASTIT HGLYKRTPRY PEELELLVSQ QSPCGRATSS SRVWWDSSFL GGVVHLEAGE KVVVRVLDER LVRLRDGTRS YFGAFMV
Molecular Weight: Approximately 50 kDa
References & Citations: [1]Mauri DN, et al. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Immunity. 1998 Jan;8(1):21-30.|[2]Han M, et al. Comprehensive characterization of TNFSF14/LIGHT with implications in prognosis and immunotherapy of human gliomas. Front Immunol. 2022 Oct 20;13:1025286.|[3]Manresa MC, et al. LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms. Mucosal Immunol. 2022 Feb;15(2):327-337.|[4]Hou Y, et al. Dual Roles of Tumor Necrosis Factor Superfamily 14 in Antiviral Immunity. Viral Immunol. 2022 Nov;35(9):579-585.|[5]Miao X, et al. HES5-mediated repression of LIGHT transcription may contribute to apoptosis in hepatocytes. Cell Death Discov. 2021 Oct 23;7(1):308.|[6]Zhang H, et al. TNFSF14, a novel target of miR-326, facilitates airway remodeling in airway smooth muscle cells via inducing extracellular matrix protein deposition and proliferation. Kaohsiung J Med Sci. 2020 Jul;36(7):508-514.|[7]Holmes TD, et al. Licensed human natural killer cells aid dendritic cell maturation via TNFSF14/LIGHT. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5688-96.
Shipping Conditions: Blue Ice
Storage Conditions: Stored at -20°C for 2 years

Complementary Product Range

Our range of products, including LIGHT/TNFSF14, Human (HEK293, Fc), falls within the same field of application and can be used across various research projects. These products are carefully selected for their high performance and reliability, supporting the diverse needs of modern laboratories. Whether for ongoing studies or future experiments, they are designed to help researchers achieve their scientific goals. Here are some related products that may be of interest for similar or future applications:

Each item in our collection, is tested for precision and quality, ensuring dependable solutions for your research. As we continue to incorporate the latest advancements, Gentaur ensures that our product range remains relevant and versatile, providing you with the tools needed for both current and future projects.

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Cat	Name
HY-P72522-01	LIGHT/TNFSF14, Human (HEK293, His)
HY-P73281-01	LIGHT/TNFSF14, Human (HEK293, Fc)
HY-P73281-02	LIGHT/TNFSF14, Human (HEK293, Fc)
HY-P72522-02	LIGHT/TNFSF14, Human (HEK293, His)
HY-P73281-03	LIGHT/TNFSF14, Human (HEK293, Fc)
HY-P72033-02	LIGHT/TNFSF14, Human (HEK293, hFC-Myc)
HY-P72033-03	LIGHT/TNFSF14, Human (HEK293, hFC-Myc)
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