Toxin B from Clostridium difficile

• Description:

  Toxin B from Clostridium difficile_x000D_ Catalog number: B2017253_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 µg_x000D_ Molecular Weight or Concentration: N/A_x000D_ Supplied as: Powder_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: 2-8°C_x000D_ Keywords: N/A_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Kuehne SA, Cartman ST, Heap JT, Kelly ML, Cockayne A, Minton NP. The role of toxin A and toxin_B in Clostridium difficile infection Nature. 2010 Oct 7;467(7316):711-3._x000D_ 2: Chandrasekaran R, Lacy DB. The role of toxins in Clostridium_difficile infection FEMS Microbiol Rev. 2017 Nov 1;41(6):723-750._x000D_ 3: Aktories K, Schwan C, Jank T. Clostridium difficile Toxin_Biology Annu Rev Microbiol. 2017 Sep 8;71:281-307._x000D_ 4: Drudy D, Fanning S, Kyne L. Toxin A-negative, toxin B-positive Clostridium difficile Int J Infect Dis. 2007 Jan;11(1):5-10._x000D_ 5: Carter GP, Rood JI, Lyras D. The role of toxin A and toxin_B in the virulence of Clostridium difficile Trends Microbiol. 2012 Jan;20(1):21-9._x000D_ 6: Lyras D, O'Connor JR, Howarth PM, Sambol SP, Carter GP, Phumoonna T, Poon R, Adams V, Vedantam G, Johnson S, Gerding DN, Rood JI. Toxin_B is essential for virulence of Clostridium_difficile Nature. 2009 Apr 30;458(7242):1176-9._x000D_ 7: Jank T, Giesemann T, Aktories K. Clostridium difficile glucosyltransferase toxin_B-essential amino acids for substrate binding J Biol Chem. 2007 Nov 30;282(48):35222-31._x000D_ 8: Luo P, Liu Y. Detection of toxin B of Clostridium difficile based on immunomagnetic separation and aptamer-mediated colorimetric assay Lett Appl Microbiol. 2020 Dec;71(6):596-604._x000D_ 9: Aldape MJ, Heeney DD, Bryant AE, Stevens DL. Tigecycline suppresses toxin A and B production and sporulation in Clostridium difficile J Antimicrob Chemother. 2015 Jan;70(1):153-9._x000D_ 10: Aminzadeh A, Jørgensen R. Systematic Evaluation of Parameters Important for Production of Native Toxin A and Toxin B from Clostridioides difficile Toxins (Basel). 2021 Mar 27;13(4):240. _x000D_ _x000D_ Products Related to Toxin B from Clostridium_difficile can be found at Proteins

• Short Description:

  Catalog Number: B2017253 (50 µg)_x000D_ Toxin B, also known as TcdB, is a major virulence factor produced by Clostridium difficile (C. difficile), a Gram-positive, spore-forming anaerobic bacterium. Toxin B is a glucosyltransferase that targets small GTPases of the Rho family, disrupting the actin cytoskeleton and leading to cell death. Along with Toxin A, it contributes to the pathogenesis of C. difficile infection. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5