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SirReal-1

CAT: 0804-HY-123653Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123653Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SirReal-1 is a potent and selective Sirt2 inhibitor (IC50 = 3.7 uM) [1].
CAS Number
801227-82-7
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Assay Protocol
https://www.medchemexpress.com/sirreal-1.html
Smiles
O=C(CSC1=NC(C)=CC(C)=N1)NC2=NC=C(CC3=CC=CC=C3)S2
Molecular Formula
C18H18N4OS2
Molecular Weight
370.49
References & Citations
[1]Rumpf T, Schiedel M, Karaman B, et al. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nat Commun. 2015;6:6263. |[2]Schiedel M, Rumpf T, Karaman B, et al. Structure-Based Development of an Affinity Probe for Sirtuin 2. Angew Chem Int Ed Engl. 2016;55 (6) :2252-2256.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT2

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