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SirReal2 (Standard)

CAT: 0804-HY-100591RSize: 1 EachDry Ice: NoHazardous: No
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Description
SirReal2 (Standard) is the analytical standard of SirReal2. This product is intended for research and analytical applications. SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1. SirReal2 combined with VS-5584 (HY-16585) suppresses tumor growth and extends the survival rate of mice in tumor xenograft model. SirReal2 is is promising for research of cancer, inflammation and neurodegeneration[1][2][3][4].
CAS Number
709002-46-0
Target
Reference Standards; Sirtuin
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Others
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Smiles
O=C(NC1=NC=C(CC2=C3C=CC=CC3=CC=C2)S1)CSC4=NC(C)=CC(C)=N4
Molecular Formula
C22H20N4OS2
Molecular Weight
420.55
References & Citations
[1]Rumpf T, et al. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nat Commun. 2015 Feb 12;6:6263.|[2]Schiedel M, et al. Structure-Based Development of an Affinity Probe for Sirtuin 2. Angew Chem Int Ed Engl. 2016;55 (6) :2252-2256. |[3]Luo Y, et al. SIRT2 inhibitor SirReal2 enhances anti-tumor effects of PI3K/mTOR inhibitor VS-5584 on acute myeloid leukemia cells. Cancer Med. 2023 Sep;12 (18) :18901-18917.|[4]Zhang M, et al. SIRT2 promotes murine melanoma progression through natural killer cell inhibition. Sci Rep. 2021 Jun 21;11 (1) :12988.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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Alternative Products

CatalogName
466141-01SirReal2
A15902-5SirReal2 5mg
A15902-2SirReal2 2mg
A15902-100SirReal2 100mg
A15902-10SirReal2 10mg
A15902-1SirReal2 1mg
A15902-50SirReal2 50mg
A15902-25SirReal2 25mg
M12854SirReal2 (b)

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