MAT-POS-e194df51-1

CAT: 0804-HY-157154-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-157154-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

MAT-POS-e194df51-1 is an orally active, non-covalent and non-peptide SARS-CoV-2 main protease (Mpro) inhibitor with an IC50 value of 37nM. MAT-POS-e194df51-1 is cytotoxic with EC50 values of 64 nM and 126 nM in A549-ACE2-TMPRSS2 cells and HeLa -ACE2 cells, respectively[1].

CAS Number

2765433-05-2

UNSPSC

12352005

Target

SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/mat-pos-e194df51-1.html

Purity

98.45

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N#CC1(CC1)CS(=O)(N2CC3=C([C@@H](C2)C(NC4=C5C=CC=CC5=CN=C4)=O)C=C(C=C3)Cl)=O

Molecular Formula

C24H21ClN4O3S

Molecular Weight

480.97

References & Citations

[1]Boby ML, et al. Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science. 2023 Nov 10;382 (6671) :eabo7201.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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