Sodium aescinate

• UNSPSC Description:

  Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities[1]. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway[2].

• Target Antigen:

  NF-κB

• Type:

  Natural Products

• Related Pathways:

  NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/sodium-aescinate.html

• Purity:

  99.26

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)

• Smiles:

  CC(C(OC[C@@]12[C@H]3C[C@]4(C)C([C@]1([H])CC(C)(C)[C@H](O3)[C@@H]2O)=CC[C@@]5([H])[C@@]4(C)CC[C@]6([H])[C@]5(C)CC[C@H](O[C@@H]7O[C@H](C(O[Na])=O)[C@@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O[C@@H]9OC[C@@H](O)[C@H](O)[C@H]9O)[C@]6(CO)C)=O)C(OC(C)=O)C

• Molecular Weight:

  1123.21

• References & Citations:

  [1]Zhang Z, et al. The Efficacy of Sodium Aescinate on Cutaneous Wound Healing in Diabetic Rats. Inflammation. 2015 Oct;38(5):1942-8.|[2]Hou H, et al. CARMA3/NF-κB signaling contributes to tumorigenesis of hepatocellular carcinoma and is inhibited by sodium aescinate. World J Gastroenterol. 2019 Sep 28;25(36):5483-5493.|[3]Qi SM, et al. Effect of sodium aescinate in inducing human breast cancer MCF-7 cells apoptosis by inhibiting AKT, ERK and upstream signal SRC activity. Zhongguo Zhong Yao Za Zhi. 2015 Aug;40(16):3267-72.|[4]Chen L, et al. Effect of sodium aescinate treatment on PCOS rat model with insulin resistance. Bratisl Lek Listy. 2017;118(4):223-227.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  Launched

• CAS Number:

  20977-05-3