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Methiothepin (mesylate)

CAT: 0804-HY-107836-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107836-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methiothepin (Metitepine) mesylate is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C) .
CAS Number
74611-28-2
Product Name Alternative
Metitepine (mesylate) ; Ro 8-6837 (mesylate)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/methiothepin-mesylate.html
Purity
99.60
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CN1CCN(C2CC3=CC=CC=C3SC4=CC=C(SC)C=C24)CC1.CS(=O)(O)=O
Molecular Formula
C21H28N2O3S3
Molecular Weight
452.65
Precautions
H302, H315, H319, H335
References & Citations
[1]Schoeffter P, et al. 5-Hydroxytryptamine (5-HT) -induced endothelium-dependent relaxation of pig coronary arteries is mediated by 5-HT receptors similar to the 5-HT1D receptor subtype. J Pharmacol Exp Ther. 1990 Jan;252 (1) :387-95.|[2]Knight AR, et al. Pharmacological characterisation of the agonist radioligand binding site of 5-HT (2A), 5-HT (2B) and 5-HT (2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370 (2) :114-23. Epub 2004 Jul 30.|[3]Hoyer D, et al. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin) . Pharmacol Rev. 1994 Jun;46 (2) :157-203.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT2 Receptor;5-HT5 Receptor;5-HT6 Receptor;5-HT7 Receptor; mLAG-3; MUC2; MUC3; Prostaglandin D Synthase; α-1 microglobulin

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