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Methiothepin

CAT: 0804-HY-111491Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-111491Size:1 Each
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Description
Methiothepin (Metitepine; Ro 8-6837) is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C) .
CAS Number
20229-30-5
Product Name Alternative
Metitepine; Ro 8-6837
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Methiothepin.html
Smiles
CN1CCN(C2CC3=CC=CC=C3SC4=CC=C(SC)C=C24)CC1
Molecular Formula
C20H24N2S2
Molecular Weight
356.55
Precautions
P261-P280-P302+P352
References & Citations
[1]Schoeffter P, et al. 5-Hydroxytryptamine (5-HT) -induced endothelium-dependent relaxation of pig coronary arteries is mediated by 5-HT receptors similar to the 5-HT1D receptor subtype. J Pharmacol Exp Ther. 1990 Jan;252 (1) :387-95.|[2]Knight AR, et al. Pharmacological characterisation of the agonist radioligand binding site of 5-HT (2A), 5-HT (2B) and 5-HT (2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370 (2) :114-23. Epub 2004 Jul 30.|[3]Hoyer D, et al. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin) . Pharmacol Rev. 1994 Jun;46 (2) :157-203.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT2 Receptor;5-HT5 Receptor;5-HT6 Receptor;5-HT7 Receptor

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