PF-06928215

• Product Name Alternative:

  BafA1

• UNSPSC Description:

  PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 μΜ. PF-06928215 has a high binding affinity of 0.2 μM (Kd)[1].

• Target Antigen:

  Cyclic GMP-AMP Synthase

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/PF-06928215.html

• Purity:

  99.69

• Solubility:

  DMSO : 33.33 mg/mL (ultrasonic)

• Smiles:

  OC1=CC(C2=CC=CC=C2)=NC3=C(C(N[C@H]4CCCC[C@H]4C(O)=O)=O)C=NN13

• Molecular Weight:

  380.40

• References & Citations:

  [1]Hall J, et al. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS One. 2017 Sep 21;12(9):e0184843.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  2378173-15-8