Products for Research Use Only
RegisterLogin

Dimethyl lithospermate B

CAT: 0804-HY-N6868-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-N6868-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to increased inward current during the early phases of the action potential (AP) [1][2].
CAS Number
875313-64-7
Product Name Alternative
DmLSB
UNSPSC
12352005
Target
Sodium Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/dimethyl-lithospermate-b.html
Purity
99.40
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C(O)C=CC(C[C@H](C(OC)=O)OC([C@H]2C3=C(/C=C/C(O[C@@H](C(OC)=O)CC4=CC(O)=C(O)C=C4)=O)C=CC(O)=C3O[C@@H]2C5=CC(O)=C(O)C=C5)=O)=C1
Molecular Formula
C38H34O16
Molecular Weight
746.67
References & Citations
[1]Fish JM, et al. Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome. Circulation. 2006 Mar 21;113 (11) :1393-400.|[2]Yoon JY, et al. A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes. Br J Pharmacol. 2004 Nov;143 (6) :765-73.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Related Products

CatalogName
HY-126415-01Magnesium Lithospermate B
HY-N8931Monomethyl lithospermate
HY-128454-01Dimethyl trisulfide
HY-N7106-01Dimethyl phthalate
HY-W013466-01Dimethyl decanedioate
HY-W998687-01Cy5 dimethyl
HY-B2062-01Chlorthal-dimethyl
HY-N1277Dimethyl secologanoside
HY-165713Dimethyl docosanedioate
HY-W098047-01Dimethyl octadecanedioate

Alternative Products

CatalogName
AB1778Dimethyl lithospermate B
371371Dimethyl lithospermate B discontinued
MBS5761801Monomethyl lithospermate
GTR19217260-01Lithospermate B
N2234-5Monomethyl lithospermate B
380759Magnesium Lithospermate B
GTR19158894-019'-Methyl lithospermate B
sc-268930Dimethyl 2,2-dimethyl-malonate
FD62526Dimethyl Phthalate
GTR19203502-01Chlorthal-dimethyl

Popular Products