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Monomethyl lithospermate

CAT: 0804-HY-N8931Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N8931Size:1 Each
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Description
Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS) [1].
CAS Number
933054-33-2
Product Name Alternative
Lithospermic acid monomethyl ester
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Akt
Type
Natural Products
Related Pathways
PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/monomethyl-lithospermate.html
Solubility
10 mM in DMSO
Smiles
O=C(/C=C/C1=C2C(O[C@@H]([C@H]2C(OC)=O)C3=CC(O)=C(O)C=C3)=C(O)C=C1)O[C@H](CC4=CC(O)=C(O)C=C4)C(O)=O
Molecular Formula
C28H24O12
Molecular Weight
552.48
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Yang F, et al. Monomethyl lithospermate alleviates ischemic stroke injury in middle cerebral artery occlusion mice in vivo and protects oxygen glucose deprivation/reoxygenation induced SHSY-5Y cells in vitro via activation of PI3K/Akt signaling. Front Pharmacol. 2022 Oct 13;13:1024439.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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