Human DEDD Protein

Human DEDD Protein_x000D_ Catalog number: B2012144_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 µg_x000D_ Molecular Weight or Concentration: 500 µg/mL_x000D_ Supplied as: Solution_x000D_ Applications: molecular tool for various biochemical applications_x000D_ Storage: -20 °C_x000D_ Keywords: DEDD1 protein, KE05 protein, Death effector domain-containing protein , DEFT protein, FLDED1 protein, CASP8IP1 protein_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus EMBO J. 1998 Oct 15;17(20):5974-86._x000D_ 2: Hong AL, Guerriero JL, Doshi MB, Kynnap BD, Kim WJ, Schinzel AC, Modiste R, Schlauch AJ, Adam RM, Kwiatkowski DJ, Beroukhim R, Letai A, Rosenberg JE, Hahn WC. MCL1 and DEDD Promote Urothelial Carcinoma Progression Mol Cancer Res. 2019 Jun;17(6):1294-1304._x000D_ 3: Liu D, Qin X, Sun Z, Hou S, Lv Q. Low DEDD expression in breast cancer cells indicates higher sensitivity to the Bcl-2-specific inhibitor ABT-199 Biochem Biophys Res Commun. 2020 May 7;525(3):549-556._x000D_ 4: Lv Q, Wang W, Xue J, Hua F, Mu R, Lin H, Yan J, Lv X, Chen X, Hu ZW. DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer Cancer Res. 2012 Jul 1;72(13):3238-50._x000D_ 5: Mori M, Kitazume M, Ose R, Kurokawa J, Koga K, Osuga Y, Arai S, Miyazaki T. Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice J Clin Invest. 2011 Jan;121(1):318-27._x000D_ 6: Huang X, Zhang M, Tang H, Ruo C, Cao X. Identification and characterization of DEDDL, a human-specific isoform of DEDD Gene Expr. 2006;13(3):141-53._x000D_ 7: Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC Cell Death Differ. 2002 Apr;9(4):439-47._x000D_ 8: Xue JF, Hua F, Lv Q, Lin H, Wang ZY, Yan J, Liu JW, Lv XX, Yang HZ, Hu ZW. DEDD negatively regulates transforming growth factor-beta1 signaling by interacting with Smad3 FEBS Lett. 2010 Jul 16;584(14):3028-34._x000D_ 9: Lee JC, Schickling O, Stegh AH, Oshima RG, Dinsdale D, Cohen GM, Peter ME. DEDD regulates degradation of intermediate filaments during apoptosis J Cell Biol. 2002 Sep 16;158(6):1051-66._x000D_ 10: Schutte B, Henfling M, Ramaekers FC. DEDD association with cytokeratin filaments correlates with sensitivity to apoptosis Apoptosis. 2006 Sep;11(9):1561-72. _x000D_ _x000D_ Products Related to Human DEDD Protein can be found at Proteins

Catalog Number: B2012144 (50 µg)

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