Tyk2 (phospho-Tyr1054/1055) rabbit pAb

• Background:

  Tyrosine kinase 2 (TYK2) Homo sapiens This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

• Description:

  Tyrosine kinase 2 (TYK2) Homo sapiens This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II Cytokine receptors and promulgate Cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008],

• Synonyms:

  Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)

• Gene ID:

  7297

• UniProt:

  P29597

• Cellular Locus:

  Nucleus,cytoplasm,cytosol,cytoskeleton,membrane,extrinsic component of cytoplasmic side of plasma membrane,extracellular exosome,

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse,

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized phosho peptide around human Tyk2 (Tyr1054 and 1055)

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB

• Validated Applications:

  WB

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:1000-2000

• Molecular Weight:

  134kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  134 kD

• Subcellular Location:

  Nucleus, cytoplasm, cytosol, cytoskeleton, membrane, extrinsic component of cytoplasmic side of plasma membrane, extracellular exosome

• Other Product Names:

  Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)

• Gene ID (Human):

  7297

• SwissProt (Human):

  P29597