KDM4-IN-3

• UNSPSC Description:

  KDM4-IN-3 is a KDM4 inhibitor that exhibits improved potency in biochemical assays, is cell-permeable, and kills prostate cancer cells at low micromolar concentrations.

• Target Antigen:

  Histone Demethylase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/kdm4-in-3.html

• Purity:

  99.36

• Solubility:

  DMSO : 116.67 mg/mL (ultrasonic)

• Smiles:

  OC1=C(C2=CC=CC=C2)C(C)=NN1C3=NC4=CC=CC=C4N3

• Molecular Weight:

  290.32

• References & Citations:

  [1]Carter DM, et al. Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer. J Med Chem. 2021 Oct 14;64(19):14266-14282.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1068515-53-6