AMI-1

CAT: 0804-HY-18962-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0804-HY-18962-01Size:10 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
AMI-1 is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 exerts PRMTs inhibitory effects by blocking peptide-substrate binding[1].
CAS Number
[20324-87-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AMI-1.html
Concentration
10mM
Purity
98.0
Solubility
H2O : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=CC2=CC(S(=O)(O[Na])=O)=CC(O)=C2C=C1)NC3=CC4=CC(S(=O)(O[Na])=O)=CC(O)=C4C=C3
Molecular Formula
C21H14N2Na2O9S2
Molecular Weight
548.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang, B., et al. Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3. Oncotarget. 2015 Sep 8;6 (26) :22799-811.|[2]Baolai Zhang, et al. Arginine Methyltransferase inhibitor-1 Inhibits Sarcoma Viability in vitro and in vivo. Oncol Lett. 2018 Aug;16 (2) :2161-2166.|[3]Donghang Cheng, et al. Small Molecule Regulators of Protein Arginine Methyltransferases. J Biol Chem. 2004 Jun 4;279 (23) :23892-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT1
Citation 01
Cell Death Dis. 2023 Sep 22;14 (9) :624.|Cell Death Dis. 2024 Nov 11;15 (11) :814.|Genes Dis. 2023 Mar 28;10 (6) :2622-2638.|Nat Commun. 2023 Feb 23;14 (1) :1011.|Cell Rep. 2024 Aug 22;43 (9) :114662.|Cell Rep. 2024 Jul 24;43 (8) :114537.

Related Products

CatalogName
HY-164456AMI-408
HY-N6838-011,1,1,1-Kestohexaose
HY-157129AMPK-α1β1γ1 activator 1
HY-1336231,1,1-Tribromoacetone
HY-W160628S1,1,1-Trimethoxypropane-d5
HY-149536TWIK-1/TREK-1-IN-1
HY-133630-011-Bromo-1,1-dichloroacetone
HY-W032015S11-Bromooctane-1,1-d2
HY-1336291,1,1,3-Tetrachloroacetone
HY-W881439-011- (1,1-Dimethylethyl) tridecanedioate

Alternative Products

CatalogName
M13165-01AMI-1
A15916-10AMI-1 10mg
A15916-5AMI-1 5mg
A15916-25AMI-1 25mg
A15916-50AMI-1 50mg
A15916-100AMI-1 100mg
A15916-500AMI-1 500mg
sc-205928AAMI-1, sodium salt
MBS5802359AMI-1, free acid
27307AMI-1 (sodium salt)

Popular Products