AMI-408

• Description :

  AMI-408 is a PRMT1 inhibitor. AMI-408 can reduce H4R3me2as level in MLL-GAS7 leukemia cells[1].

• CAS Number :

  [78866-14-5]

• UNSPSC :

  12352005

• Target :

  Histone Methyltransferase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ami-408.html

• Smiles :

  O=S(C1=C(/N=N/C2=CC=C(OC)C=C2)C(O)=C3C=CC(NC4=NC(Cl)=NC(Cl)=N4)=CC3=C1)(O[Na])=O

• Molecular Formula :

  C20H13Cl2N6NaO5S

• Molecular Weight :

  543.32

• References & Citations :

  [1]Cheung N, et al. Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia. Cancer Cell. 2016 Jan 11;29 (1) :32-48.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PRMT1