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NGAL rabbit pAb

CAT: 0855-ES20354-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES20354-01Size:50 µL
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Background
This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015]
Description
This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015],
UniProt
P80188
Swiss Prot
P80188
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human NGAL
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:1000-2000 ELISA 1:5000-20000
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Secreted . Cytoplasmic granule lumen . Cytoplasmic vesicle lumen . Upon binding to the SLC22A17 (24p3R) receptor, it is internalized (By similarity) . Releases the bound iron in the acidic lumen of cytoplasmic vesicles (PubMed:12453413, PubMed:20581821) . .
Other Product Names
Neutrophil gelatinase-associated lipocalin (NGAL;25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25)

UniProtKB · P80188

Neutrophil gelatinase-associated lipocalin

NGAL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P80188
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LCN2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
NGAL
EC number
—
Processing
Precursor
Secondary accessions
A6NII8, B4DWV4, B7ZAA2, P30150, Q5SYV9, Q5SYW0, Q6FGL5, Q92683
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisImmunityInnate immunityIon transportIron transportTransport

Cellular component

Cytoplasmic vesicleSecreted

PTM

Disulfide bondGlycoproteinPyrrolidone carboxylic acid

Ligand

Iron

Domain

Signal

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