PF-07328948

CAT: 0804-HY-159648-01Size: 1 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-159648-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

PF-07328948 is an orally effective BDK (branch chain ketoacid dehydrogenase kinase) inhibitor, with IC50 of 110 nM. PF-07328948 acts as a BCKDH (branch chain ketoacid dehydrogenase) enzyme complex degrader to enhance BCAA (branch chain amino acid) catabolism. PF-07328948 improves metabolic and heart failure end points in rats[1].

CAS Number

2936625-34-0

UNSPSC

12352101

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pf-07328948.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=C(C=C(C(F)=C1OC)C2=C(C(O)=O)SC3=CC(F)=CC=C23)F

Molecular Formula

C16H8F4O3S

Molecular Weight

356.29

References & Citations

[1]Filipski KJ, et al. Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948. J Med Chem. 2024 Nov 19.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Related Products

Catalog	Name
HY-P991569	PF-04840082
HY-120689-01	PF-04745637
HY-160603-01	PF-05214030
HY-101383-01	PF-01247324
HY-12883A-01	PF-05198007
HY-15773-01	PF-4708671
HY-120072-01	PF-3450074
HY-100873-01	PF-1355
HY-119190-01	PF-06445974
HY-111371-01	PF-05180999

Alternative Products

Catalog	Name
T88836-01	PF-07328948
MBS579460	PF-03084014 (PF-3084014)
M36412-01	PF-17
M34376-01	PF-184298
M33060-01	PF-04957325
M28021-01	PF-1355
M26783-01	PF-04937319
M26368-01	PF-04885614
M24156-01	PF-9363
M23628-01	PF-06424439

PF-07328948

Related Products

Alternative Products

Popular Products