Colchiceine

CAT: 0804-HY-127166-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-127166-01Size:1 mg
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Description
Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569) . Colchicine is a tubulin inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis[1][2][3].
CAS Number
[477-27-0]
Product Name Alternative
O10-Demethylcolchicine
UNSPSC
12352005
Hazard Statement
H302, H315, H318, H335
Target
Microtubule/Tubulin
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/colchiceine.html
Purity
98.1
Solubility
10 mM in DMSO
Smiles
CC(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(O)C2=O)=O
Molecular Formula
C21H23NO6
Molecular Weight
385.41
Precautions
H302, H315, H318, H335
References & Citations
[1]Rodríguez L, et al. Effects of colchicine and colchiceine in a biochemical model of liver injury and fibrosis. Arch Med Res. 1998;29 (2) :109-116.|[2]Edström A, et al. Inhibition of fast axonal transport and microtubule polymerization in vitro by colchicine and colchiceine. Acta Physiol Scand. 1979;107 (3) :233-237.|[3]Nava-Ocampo AA, et al. Effect of colchiceine and ursodeoxycholic acid on hepatocyte and erythrocyte membranes and liver histology in experimentally induced carbon tetrachloride cirrhosis in rats. Eur J Clin Invest. 1997;27 (1) :77-84.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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Alternative Products

CatalogName
TRC-C638500-10MGColchiceine
TRC-C638502-25MGColchiceine-d3
TRC-D198900-100MGN-Deacetyl Colchiceine
007548(R/S) -N-Deacetyl Colchiceine
MBS6031779-01(R/S)-N-Deacetyl Colchiceine
D1770-10-01N-Deacetyl Colchiceine (Trimethyl Colchicinic Acid)
TRC-D198905-10MG(R/S)-N-Deacetyl Colchiceine N-Trifluroracetate
007549(R/S) -N-Deacetyl Colchiceine N-Trifluroracetate
296935-01(R/S) -N-Deacetyl colchiceine N-trifluoroacetate
C7506-99Colchiceine-d3 (N-[ (7S) -5,6,7,9-Tetrahydro-10-hydroxy-1,2,3, -trimethoxy-9-oxobenzo[a]heptalen-7-yl]-acetamide)

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