Oleanolic acid

• Description :

  Oleanolic acid (Caryophyllin) is a natural compound from plants with anti-tumor activities.

• Product Name Alternative :

  Oleanic acid; Caryophyllin

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Autophagy; Endogenous Metabolite; HIV; MAP3K

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Autophagy; MAPK/ERK Pathway; Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Oleanolic-Acid.html

• Purity :

  98.0

• Solubility :

  DMF : 45.45 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 5 mg/mL (ultrasonic)

• Smiles :

  C[C@]([C@@]1([H])[C@]2(CC[C@@H]3O)C)(CC[C@@]2([H])C3(C)C)[C@@](C4=CC1)(CC[C@]5(C(O)=O)[C@@]4([H])CC(C)(C)CC5)C

• Molecular Formula :

  C30H48O3

• Molecular Weight :

  456.70

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Zhao X, et al. Oleanolic acid suppresses the proliferation of lung carcinoma cells by miR-122/Cyclin G1/MEF2D axis. Mol Cell Biochem. 2015 Feb;400 (1-2) :1-7.|[2]Liu J, et al. Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy. J Nutr Biochem. 2014 Nov;25 (11) :1154-60.|[3]Liu J, et al. p38 MAPK signaling mediates mitochondrial apoptosis in cancer cells induced by oleanolic acid. Asian Pac J Cancer Prev. 2014;15 (11) :4519-25.|[4]Martín R, et al. Oleanolic acid modulates the immune-inflammatory response in mice with experimental autoimmune myocarditis and protects from cardiac injury. Therapeutic implications for the human disease. J Mol Cell Cardiol. 2014 Jul;72:250-62.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• Isoform :

  MAP3K5/ASK1

• CAS Number :

  [508-02-1]