Oleanonic acid

• Description :

  Oleanonic acid (3-Oxooleanolic acid) is an orally available triterpene that has anti-inflammatory and insecticidal properties. In vitro, oleanonic acid can improve oxidative stress, autophagy defects, ferroptosis, mitochondrial damage, and endoplasmic reticulum stress induced by Amyloid-β, and in vivo, it can alleviate myocardial hypertrophy in rats[1][2][3][4][5].

• Product Name Alternative :

  3-Oxooleanolic acid

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Amyloid-β; Autophagy; Ferroptosis; HIV

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Apoptosis; Autophagy; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Infection; Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Oleanonic-acid.html

• Purity :

  99.63

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  CC1(C)C(CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])CC(C)(C)CC[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=O

• Molecular Formula :

  C30H46O3

• Molecular Weight :

  454.68

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Giner-Larza EM et al.Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity.Eur J Pharmacol.Sep 28;428 (1) :137-43.doi:10.1016/S0014-2999 (01) 01290-0 (2001) |[2]Fabio Mengoni.Anti-HIV Activity of Oleanolic Acid on Infected Human Mononuclear Cells.Planta Med 68 (2) : 111-114.DOI: 10.1055/s-2002-20256 (2002) |[3]Cristiano S. FUNARI, et al. Oleanonic acid from Lippia lupulina (Verbenaceae) .shows strong in vitro antileishmanial and antitrypanosomal activity. Acta Amazonica. 46 (4) .Oct-Dec 2016 |[4]Hui Gao, et al. Oleanonic acid ameliorates pressure overload-induced cardiac hypertrophy in rats: The role of PKCζ-NF-κB pathway. Mol Cell Endocrinol. 2018 Jul 15:470:259-268.|[5]Liqing Tao, et al. Oleanonic acid ameliorates mutant Aβ precursor protein-induced oxidative stress, autophagy deficits, ferroptosis, mitochondrial damage, and ER stress in vitro. Biochim Biophys Acta Mol Basis Dis. 2024 Dec;1870 (8) :167459.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  HIV-1

• CAS Number :

  [17990-42-0]