Oleanonic acid

CAT: 0804-HY-N1487-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N1487-01Size:25 mg
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Description
Oleanonic acid (3-Oxooleanolic acid) is an orally available triterpene that has anti-inflammatory and insecticidal properties. In vitro, oleanonic acid can improve oxidative stress, autophagy defects, ferroptosis, mitochondrial damage, and endoplasmic reticulum stress induced by Amyloid-β, and in vivo, it can alleviate myocardial hypertrophy in rats[1][2][3][4][5].
CAS Number
[17990-42-0]
Product Name Alternative
3-Oxooleanolic acid
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Amyloid-β; Autophagy; Ferroptosis; HIV
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Oleanonic-acid.html
Purity
99.63
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC1(C)C(CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])CC(C)(C)CC[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=O
Molecular Formula
C30H46O3
Molecular Weight
454.68
Precautions
H302, H315, H319, H335
References & Citations
[1]Giner-Larza EM et al.Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity.Eur J Pharmacol.Sep 28;428 (1) :137-43.doi:10.1016/S0014-2999 (01) 01290-0 (2001) |[2]Fabio Mengoni.Anti-HIV Activity of Oleanolic Acid on Infected Human Mononuclear Cells.Planta Med 68 (2) : 111-114.DOI: 10.1055/s-2002-20256 (2002) |[3]Cristiano S. FUNARI, et al. Oleanonic acid from Lippia lupulina (Verbenaceae) .shows strong in vitro antileishmanial and antitrypanosomal activity. Acta Amazonica. 46 (4) .Oct-Dec 2016 |[4]Hui Gao, et al. Oleanonic acid ameliorates pressure overload-induced cardiac hypertrophy in rats: The role of PKCζ-NF-κB pathway. Mol Cell Endocrinol. 2018 Jul 15:470:259-268.|[5]Liqing Tao, et al. Oleanonic acid ameliorates mutant Aβ precursor protein-induced oxidative stress, autophagy deficits, ferroptosis, mitochondrial damage, and ER stress in vitro. Biochim Biophys Acta Mol Basis Dis. 2024 Dec;1870 (8) :167459.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HIV-1

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