PPI-GIT1/β-Pix interaction-IN-1

PPI-GIT1/β-Pix interaction-IN-1

• CAS Number: 2070916-70-8
• UNSPSC Description: PPI-GIT1/β-Pix interaction-IN-1 is a potent and orally active GIT1/β-Pix protein-protein interaction (PPI) inhibitor with a KD value of 7.7 µM. PPI-GIT1/β-Pix interaction-IN-1 disrupts the GIT/PIX interaction can impact the activation of the downstream Rho GTPase Rac1 and Cdc42. PPI-GIT1/β-Pix interaction-IN-1 inhibits metastasis of gastric cancer[1].
• Target Antigen: Ras
• Type: Reference compound
• Related Pathways: GPCR/G Protein;MAPK/ERK Pathway
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ppi-git1-β-pix-interaction-in-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C([C@@H]1[C@@H](C(OCC)=O)[C@]2(C(N(C)C3=C2C=CC=C3)=O)[C@H]/4C1)C4=C\C5=COC=C5
• Molecular Weight: 391.42
• References & Citations: [1]Gu J, et, al. Construction of a synthetic methodology-based library and its application in identifying a GIT/PIX protein-protein interaction inhibitor. Nat Commun. 2022 Nov 23;13(1):7176.|[2]Gu J, et, al. Construction of a synthetic methodology-based library and its application in identifying a GIT/PIX protein-protein interaction inhibitor. Nat Commun. 2022 Nov 23;13(1):7176.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported