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DPBQ

CAT: 0804-HY-U00441-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-U00441-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DPBQ activates p53 and triggers apoptosis in a polyploid-specific manner, but does not inhibit topoisomerase or bind DNA. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells[1].
CAS Number
7029-89-2
UNSPSC
12352005
Target
Apoptosis; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/DPBQ.html
Purity
99.46
Solubility
DMSO : 2.94 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(C1=CC=CC=C12)C3=C(N=C(C4=CC=CC=C4)C(C5=CC=CC=C5)=N3)C2=O
Molecular Formula
C24H14N2O2
Molecular Weight
362.38
References & Citations
[1]Choudhary A, et al. Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer. Mol Cancer Ther. 2016;15 (1) :48-59.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2,3-Diphenylbenzo[g]quinoxaline-5,10-dione
CAS Number7029-89-2
PubChem CID364074
IUPAC Name2,3-diphenylbenzo[g]quinoxaline-5,10-dione
Molecular FormulaC24H14N2O2
Molecular Weight362.4
XLogP4.7
Topological Polar Surface Area59.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count28
Formal Charge0
Complexity541
SMILES
C1=CC=C(C=C1)C2=C(N=C3C(=N2)C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5
InChI
InChI=1S/C24H14N2O2/c27-23-17-13-7-8-14-18(17)24(28)22-21(23)25-19(15-9-3-1-4-10-15)20(26-22)16-11-5-2-6-12-16/h1-14H
InChIKey
BDDRJIAFKGWLMD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2,3-Diphenylbenzo[g]quinoxaline-5,10-dione
CAS: 7029-89-2
CID: 364074
Formula: C24H14N2O2
MW: 362.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight362.4
XLogP34.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass362.105527694
Monoisotopic Mass362.105527694
Topological Polar Surface Area59.9 Ų
Heavy Atom Count28
Formal Charge0
Complexity541
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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