Yangonin (Standard)

• UNSPSC Description:

  Yangonin (Standard) is the analytical standard of Yangonin. This product is intended for research and analytical applications. Yangonin exhibits affinity for the human recombinant cannabinoid CB1 receptor with an IC50 and a Ki of 1.79 μM and 0.72 μM, respectively.

• Target Antigen:

  Autophagy; Cannabinoid Receptor; NF-κB

• Type:

  Reference Standards

• Related Pathways:

  Autophagy;GPCR/G Protein;Neuronal Signaling;NF-κB

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/yangonin-standard.html

• Smiles:

  O=C1C=C(OC)C=C(/C=C/C2=CC=C(OC)C=C2)O1

• Molecular Weight:

  258.27

• References & Citations:

  [1]Ligresti A, et al. Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB₁ receptor ligand. Pharmacol Res. 2012 Aug;66(2):163-9.|[2]Ma J, et al. Yangonin blocks tumor necrosis factor-α-induced nuclear factor-κB-dependent transcription by inhibiting the transactivation potential of the RelA/p65 subunit. J Pharmacol Sci. 2012;118(4):447-54.|[3]Wruck CJ, et al. Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation. Mol Pharmacol. 2008 Jun;73(6):1785-95.

• Shipping Conditions:

  Room temperature

• CAS Number:

  500-62-9