Yangonin

• UNSPSC Description:

  Yangonin exhibits affinity for the human recombinant cannabinoid CB1 receptor with an IC50 and a Ki of 1.79 μM and 0.72 μM, respectively.

• Target Antigen:

  Autophagy; Cannabinoid Receptor; NF-κB

• Type:

  Natural Products

• Related Pathways:

  Autophagy;GPCR/G Protein;Neuronal Signaling;NF-κB

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Yangonin.html

• Purity:

  99.79

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  O=C1C=C(OC)C=C(/C=C/C2=CC=C(OC)C=C2)O1

• Molecular Weight:

  258.27

• References & Citations:

  [1]Ligresti A, et al. Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB₁ receptor ligand. Pharmacol Res. 2012 Aug;66(2):163-9.|[2]Ma J, et al. Yangonin blocks tumor necrosis factor-α-induced nuclear factor-κB-dependent transcription by inhibiting the transactivation potential of the RelA/p65 subunit. J Pharmacol Sci. 2012;118(4):447-54.|[3]Wruck CJ, et al. Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation. Mol Pharmacol. 2008 Jun;73(6):1785-95.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  500-62-9